Human-to-Rat Validation of PMI Biomarkers: A Bidirectional Cross-Species Metabolomics Study Reveals Asymmetric Translation
= 0.10), underscoring limited direct rat-to-human translation. Overall, human-derived biomarkers validated robustly in the controlled rat model proved far more reliable. These findings highlight both the potential and limitations of cross-species PMI biomarker discovery and emphasize the need for improved metadata, especially temperature history, to advance PMI modeling in forensic practice.
Authors
- Palle Villesen (ORCID: https://orcid.org/0000-0001-7589-8781)
- Albert Elmsjö (ORCID: https://orcid.org/0000-0002-8053-3100)
- Carl Söderberg (ORCID: https://orcid.org/0000-0001-7074-6578)
- Liam J. Ward (ORCID: https://orcid.org/0000-0002-3320-1461)
- Kirstine Lykke Nielsen (ORCID: https://orcid.org/0000-0002-5955-6156)
- Ida Marie Marquart Løber (ORCID: https://orcid.org/0009-0009-2281-8739)
- Henrik Green (ORCID: https://orcid.org/0000-0002-8015-5728)
Institutions
- Linköping University (SE)
- Aarhus University (DK)
- Science for Life Laboratory (SE)
- Swedish National Board of Forensic Medicine (SE)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1021/acs.analchem.6c00202
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovationsfonden
- Aarhus Universitets Forskningsfond
- Vetenskapsrådet