Design and Evaluation of Tyrosine‐Rich Antimicrobial Peptides With Quadruple Repeating Units
exerted rapid bactericidal activity by disrupting the membrane integrity of Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922. This study demonstrates that tyrosine can serve as a hydrophobic residue in the rational design of AMPs, offers a strategy for developing amphipathic AMPs with potent antimicrobial activity and low hemolytic activity.
Authors
- 梁国栋
- Heiya Na
- Jinlin Wang (ORCID: https://orcid.org/0000-0003-4625-7605)
- Xuefeng Yuan (ORCID: https://orcid.org/0000-0002-4764-4976)
- Fangping Wan (ORCID: https://orcid.org/0000-0003-1647-3278)
- Ronglin Liu
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia University (CN)
- Institute of Pharmacology (CZ)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1002/cmdc.70300
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00