MMP1 and PRSS23 induce PAR2 biased agonism in painful oral cancers
activation in oral N+ cancers from patients with pain is driven by high levels of MMP1 and PRSS23. Our study informs design of signaling and location-specific antagonists to provide more efficacious analgesia.
Authors
- Igor Dolgalev (ORCID: https://orcid.org/0000-0003-4451-126X)
- Donna G. Albertson (ORCID: https://orcid.org/0000-0002-1433-6483)
- Paulina D. Ramírez-García (ORCID: https://orcid.org/0000-0003-0971-3501)
- Nguyen Thi Minh Tu
- Zinaida Dubeykovskaya
- Brian L. Schmidt (ORCID: https://orcid.org/0000-0002-2409-8984)
- Rocco Latorre
- Leticia Arbex
Institutions
- NYU Langone Health (US)
- Pain Management Institute (US)
- New York University (US)
Publication Details
- Journal
- Communications Biology
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1038/s42003-026-10215-x
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Center for Strategic Scientific Initiatives, National Cancer Institute