Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses
, mice immunized with DCs conditioned with Tn-glycoconjugate- plus CpG displayed enhanced splenocyte proliferation, increased IFN-γ secretion, and elevated cytotoxic activity without IL-10 induction, confirming a Th1-skewed response. Collectively, these findings identify MGL2 as a critical mediator of Tn-glycoconjugate sensing and unveil a synergistic C-type lectin receptor (CLR)-TLR9 cross-talk that amplifies DC maturation and cytotoxic immunity. This study provides mechanistic insight into how specific glycan-lectin interactions fine-tune innate receptor signaling, highlighting the potential of Tn-based glycoconjugates as immunomodulatory tools for vaccine design and cancer immunotherapy.
Authors
- Christelle Ganneau
- Sylvie Bay (ORCID: https://orcid.org/0000-0002-3538-2163)
- Carolina Chiale (ORCID: https://orcid.org/0000-0002-8432-2802)
- Teresa Freire (ORCID: https://orcid.org/0000-0002-7808-8845)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- Universidad de la República de Uruguay (UY)
- Université Paris Cité (FR)
- Universidad La República (CL)
Publication Details
- Journal
- Innate Immunity
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1177/17534259261449674
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00