Site-Specific <i>In Situ</i> Metallization of Wireframe DNA Origami for Reversible Fluorescence Switching
reduction of gold ions, achieving site-specific metallization. We then incorporate a fluorescent Cy3 dye into the metallized origami template to show the distance-dependent fluorescence quenching via energy transfer. As a proof of concept, we also demonstrate the dynamic programmability of the hybrid system to remove the fluorophore by using a strand displacement reaction, resulting in complete fluorescence recovery.
Authors
- Devanathan Perumal
- Shaden Salim
- Tiffany R. Olivera (ORCID: https://orcid.org/0000-0002-4255-4920)
- Minu Saji
- Henry Wisniewski (ORCID: https://orcid.org/0000-0001-5646-7820)
- Fei Zhang (ORCID: https://orcid.org/0000-0002-3177-7547)
Institutions
- Rutgers Sexual and Reproductive Health and Rights (NL)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1021/acsnano.6c00622
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00