Two Rare Cases of Primary Hepatic Neuroendocrine Tumors: Case Reports and Literature Review

Abstract Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, making up less than 0.5% of all NETs. The liver is a common site for metastatic NET, leading to challenges in determining if a neuroendocrine neoplasm located in the liver is primary or metastatic. We report two cases of patients diagnosed with PHNETs. They were first misdiagnosed, the first case as liver hamartoma and the treatment was delayed for 4 years and the second case was first diagnosed as hepatocellular carcinoma. Although rare, the possibility of primary hepatic neuroendocrine neoplasms should be considered for a solid-cystic mass in a young patient with no known chronic liver disease and without any known primary malignancy elsewhere. Surgical resection is the most effective and reliable treatment method for patients with PHNET.