Natural Products in <i>Gambeya lacourtiana</i> (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning‐Based Pharmacokinetic Prediction
= 29.45 µg/mL). PASS analysis suggested that the isolated compounds had antineoplastic, antiproliferative, anti-inflammatory, hepatoprotective, chemopreventive, membrane integrity agonist, mucomembranous protector, insulin promoter, fibrinolytic, and antioxidant effects. In addition, isolates were projected to treat hepatic disorders, leishmaniasis, wounds, proliferative diseases, capillary fragility, hypercholesterolemia, influenza, eczema, and leukemia. Predictions on its inhibition of testosterone 17β-dehydrogenase (NADP+), a key enzyme involved in androgen metabolism, corroborate the use of this plant traditionally to solve reproductive health issues.
Authors
- Armelle T. Mbaveng (ORCID: https://orcid.org/0000-0003-4178-4967)
- Thomas Efferth (ORCID: https://orcid.org/0000-0002-2637-1681)
- Victor Kuete (ORCID: https://orcid.org/0000-0002-1070-1236)
- Japheth O. Ombito
- Bonaventure T. Ngadjui (ORCID: https://orcid.org/0000-0002-3668-4593)
- Godloves Fru Chi (ORCID: https://orcid.org/0000-0002-1484-3995)
- Marcelle O. Ngangoue
- Conrad V. Simoben (ORCID: https://orcid.org/0000-0002-5958-6961)
- Smith B. Babiaka (ORCID: https://orcid.org/0000-0002-4476-5860)
- Bathelemy Ngameni (ORCID: https://orcid.org/0000-0002-6045-0981)
Institutions
- Université de Yaoundé I (CM)
- University of Buea (CM)
- University of Botswana (BW)
- Université de Dschang (CM)
- University of Toronto (CA)
- Johannes Gutenberg University Mainz (DE)
- Ondokuz Mayıs University (TR)
- Structural Genomics Consortium (CA)
- University of Tübingen (DE)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1002/cbdv.202502045
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00