A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive‐Compulsive Symptoms in Psychiatric Genetic Studies: A Cross‐Continental Study Within the Ancestral Population Network
This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive-compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH Ancestral Population Network (APN). Five APN projects are participating in the current study (PUMAS-Paisa, PUMAS-NeuroGAP, KOMOGEN-D, LATINO, and SAX-II), spanning recruitment over 15 countries across the Americas, Africa, and Asia. Participants are being enrolled via the recruitment protocols specific to each participating project. The harmonized clinical battery includes the Columbia-Suicide Severity Scale, Snaith-Hamilton Pleasure Scale, and Florida Obsessive-Compulsive Inventory-II to assess suicidality, anhedonia, and obsessive-compulsive symptoms, respectively. Additionally, we use the Discrimination and Stigma Scale-Ultra Short to evaluate discrimination and stigma across cultures. This project is a pioneering effort to prospectively assess transdiagnostic phenotypes in large-scale, diverse ancestral and clinical populations (across different diagnoses) using a harmonized clinical battery, advancing genetic research in mental health in underrepresented populations.
Authors
- Bizu Gelaye (ORCID: https://orcid.org/0000-0001-7934-548X)
- Jonathan Flint (ORCID: https://orcid.org/0000-0002-9427-4429)
- Lukoye Atwoli (ORCID: https://orcid.org/0000-0001-7710-9723)
- Daniel Bustamante (ORCID: https://orcid.org/0000-0003-0170-2242)
- Rocky E. Stroud (ORCID: https://orcid.org/0000-0002-4246-7093)
- Stella Gichuru
- Victor I. Reus (ORCID: https://orcid.org/0000-0002-8193-5697)
- Jacey L Anderberg (ORCID: https://orcid.org/0000-0002-5434-5800)
- Sang Jin Rhee (ORCID: https://orcid.org/0000-0001-6221-5953)
- Michele T. Pato (ORCID: https://orcid.org/0000-0002-4589-7398)
- Olivia Wootton (ORCID: https://orcid.org/0000-0002-2433-4975)
- Joseph Kyebuzibwa (ORCID: https://orcid.org/0000-0003-1416-245X)
- Kristien van der Walt (ORCID: https://orcid.org/0000-0002-1864-1389)
- Shaili C. Jha (ORCID: https://orcid.org/0000-0002-1208-6839)
- Deborah Jonker (ORCID: https://orcid.org/0000-0002-7624-738X)
- Andrea Horvath Marques
- Ana M. Ramirez-Diaz
- Akena Dickens
- Susan Service
- Johanna Valencia-Echeverry
- Loes Olde Loohuis (ORCID: https://orcid.org/0000-0002-3327-7837)
- Josselyn S. Muñoz
- Ruben Gur (ORCID: https://orcid.org/0000-0002-4082-8502)
- Ezra S. Susser
- Mauricio Castano Ramirez
- Catherine E. Rast
- Renee M. Frederick (ORCID: https://orcid.org/0000-0002-3605-7151)
- Dan J. Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- Roel A. Ophoff (ORCID: https://orcid.org/0000-0002-8287-6457)
- James J. Crowley (ORCID: https://orcid.org/0000-0001-9051-1557)
- Eric A. Storch (ORCID: https://orcid.org/0000-0002-7631-3703)
- Nelson B. Freimer
- Carrie E. Bearden (ORCID: https://orcid.org/0000-0002-8516-923X)
- Carlos Lopez‐Jaramillo
- Ana M. Diaz‐Zuluaga
- Kenneth S. Kendler (ORCID: https://orcid.org/0000-0001-8689-6570)
- Yong Min Ahn (ORCID: https://orcid.org/0000-0002-4458-797X)
Institutions
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- University of Nebraska–Lincoln (US)
- Harvard University (US)
- Moi University (KE)
- University of Caldas (CO)
- University of Cape Town (ZA)
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Virginia Commonwealth University (US)
- John Sealy Hospital (US)
- Johnson University (US)
- Seoul National University Hospital (KR)
- New York Psychoanalytic Society and Institute (US)
- Universidad de Antioquia (CO)
- Behavioral Pharma (United States) (US)
- Aga Khan University Nairobi (KE)
- Aga Khan University (TZ)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Wisconsin–Milwaukee (US)
- University of Houston (US)
- Makerere University (UG)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1002/ajmg.b.70019
- Primary Topic
- Personality Disorders and Psychopathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health