MYC Unchained: Dosage-Dependent Locking of the Myeloid Fate (or Not).

MYC overexpression is a crucial element of acute myeloid leukaemia (AML) physiopathology. By advanced cellular modelling and molecular analysis, Stokes and colleagues showed that MYC overexpression induces a myeloid block. Sustained expression of this oncogene is required and sufficient to maintain the block, a feature shared by multiple AML subtypes.

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Publication Details

Journal
PubMed
Published
2026-05-08
DOI
https://doi.org/10.1016/j.exphem.2026.105443
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
0.00
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article

MYC Unchained: Dosage-Dependent Locking of the Myeloid Fate (or Not).

Alessandro Donada
PubMed
Acute Myeloid Leukemia Research
article

MYC Unchained: Dosage-Dependent Locking of the Myeloid Fate (or Not).

Alessandro Donada
article en

Abstract

MYC overexpression is a crucial element of acute myeloid leukaemia (AML) physiopathology. By advanced cellular modelling and molecular analysis, Stokes and colleagues showed that MYC overexpression induces a myeloid block. Sustained expression of this oncogene is required and sufficient to maintain the block, a feature shared by multiple AML subtypes.

PubMed
Institut Curie (FR)
Good health and well-being
Openalex Percentile: Top 4%
Acute Myeloid Leukemia Research
DOISourceOpenAlex
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