A Multi-Target Botanical Strategy for Functional Dyspepsia: Mechanistic Rationale and Physicochemical Characterization of a Ginger–Artichoke–Lemon Formulation

Background: Functional dyspepsia (FD) is a disorder of gut–brain interaction characterized by heterogeneous pathophysiological mechanisms, including altered gastric motility, visceral hypersensitivity, low-grade inflammation, impaired mucosal defence, and oxidative stress. Multi-target botanical strategies may represent a rational approach for addressing this complexity. Methods: This study evaluated the mechanistic rationale supporting a botanical formulation containing Zingiber officinale, Cynara scolymus, and Citrus limon extracts, here referred to as DyspepCyn®. A focused narrative review was conducted to summarize the available mechanistic and clinical evidence for the three botanicals. In addition, the formulation was characterized through solubility testing in aqueous and biorelevant simulated gastrointestinal media, together with antioxidant assessment using ORAC and DPPH assays. Results: DyspepCyn® showed favourable dispersion and solubility behaviour across simulated gastrointestinal conditions, with complete solubilization up to approximately 700 mg/100 mL in water and up to approximately 800 mg/100 mL in simulated intestinal fluids. No precipitation was observed in the tested media. The formulation also showed measurable antioxidant activity, with an ORAC value of 365 µmol Trolox equivalents/g and a DPPH radical scavenging EC50 of 32 µg/mL. Conclusions: DyspepCyn® combines botanicals with complementary actions on gastric motility, postprandial digestive processes, mucosal protection, and oxidative stress. The observed physicochemical stability and antioxidant capacity support the mechanistic rationale for this multi-target botanical strategy in FD. Clinical studies are required to confirm its efficacy in patients with FD.