Autopoiesis as viability-localized self-production in a topos.

Autopoiesis characterizes living organization by closure: a system maintains itself by producing and repairing the components-and crucially the boundary/interface conditions-that realize the network of production that produces them. We propose a topos-theoretic definition that (i) treats viability as an internal modality (a Lawvere-Tierney topology and its induced left-exact localization), (ii) models production/repair as a monad equipped with realization data, and (iii) makes boundary maintenance explicit via a boundary extractor, a boundary-production map, and an admissibility predicate. An autopoietic system is defined by four axioms (AP1-AP4): viability-local closure (realization becomes invertible after viability localization), produced boundaries in the viability semantics, constraint-respecting production via admissibility, and existence of at least one viable global regime. We also clarify that (AP3) is j-density of admissibility under (AP1). Finally, we illustrate consequences of the axioms on cellular sheaves over finite tissues (graphs/cell complexes), where closure reduces to equalizer/kernel tests and loopy tissues exhibit structured local-to-global obstruction signals.

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PubMed
Published
2026-05-08
DOI
https://doi.org/10.1016/j.biosystems.2026.105808
Primary Topic
Gene Regulatory Network Analysis
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article
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article

Autopoiesis as viability-localized self-production in a topos.

Juan Jose Segura
PubMed
Gene Regulatory Network Analysis
article

Autopoiesis as viability-localized self-production in a topos.

Juan Jose Segura
article en

Abstract

Autopoiesis characterizes living organization by closure: a system maintains itself by producing and repairing the components-and crucially the boundary/interface conditions-that realize the network of production that produces them. We propose a topos-theoretic definition that (i) treats viability as an internal modality (a Lawvere-Tierney topology and its induced left-exact localization), (ii) models production/repair as a monad equipped with realization data, and (iii) makes boundary maintenance explicit via a boundary extractor, a boundary-production map, and an admissibility predicate. An autopoietic system is defined by four axioms (AP1-AP4): viability-local closure (realization becomes invertible after viability localization), produced boundaries in the viability semantics, constraint-respecting production via admissibility, and existence of at least one viable global regime. We also clarify that (AP3) is j-density of admissibility under (AP1). Finally, we illustrate consequences of the axioms on cellular sheaves over finite tissues (graphs/cell complexes), where closure reduces to equalizer/kernel tests and loopy tissues exhibit structured local-to-global obstruction signals.

PubMed
Universidad Andrés Bello (CL)
Openalex Percentile: Top 7%
Gene Regulatory Network Analysis
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Autopoiesis as viability-localized self-production in a topos. — Juan Jose Segura · PubMed (2026) | TGRS Research Map | TGRS