Genetic Variant at 6p21.1 Impairs <i>APOBEC2</i> in Hypoxic Mitophagy via HIF-1α/BNIP3 in Gastric Cancer
Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) at the 6p21.1 locus associated with gastric cancer (GC) risk.However, the underlying biological mechanisms remain poorly understood.
Authors
- Shuangshuang Yin
- Yuanliang Gu
- Caiwang Yan (ORCID: https://orcid.org/0000-0002-3488-4305)
- Guangfu Jin (ORCID: https://orcid.org/0000-0003-0249-5337)
- Y Q Zhang
- Zhonghua Zheng (ORCID: https://orcid.org/0000-0002-0642-650X)
- Lu Liu (ORCID: https://orcid.org/0000-0002-0722-9241)
- Xinya Wang (ORCID: https://orcid.org/0009-0002-2537-2081)
- Xinxiang Gao
- F M An
- R L Peng
- Qiang Zhan
- Hao Xu
- Yun Gao
- Meng Zhu
- Qian Li
- Gang Li
- Xiaofeng Chen
- Erbao Zhang
Institutions
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Chongqing Public Health Medical Center (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2026-05-12
- DOI
- https://doi.org/10.4143/crt.2025.1194
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University
- National Science and Technology Major Project