Base-Promoted C→N Carbonyl Shift Enables One-Step Access to aza-β-Lactams from α-Heteroaryl-α-amino Esters
-substituents. Isolation and productive re-entry of a carbamate intermediate support a reversible manifold preceding migration and rationalize racemic product formation.
Authors
- Jozef Kristek (ORCID: https://orcid.org/0000-0001-9295-1986)
- Jiří Pospíšil (ORCID: https://orcid.org/0000-0002-0198-8116)
- Nikola Šťastná
Institutions
- Czech Academy of Sciences, Institute of Experimental Botany (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1021/acs.orglett.6c01451
- Primary Topic
- Synthesis of β-Lactam Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Palackého v Olomouci
- European Regional Development Fund