Evaluation of the properties of powder and orally disintegrating tablet (ODT) ready-to-use excipients using the direct compression method

The study aimed to formulate DFX disintegrating tablets using different types of ready-to-use excipients using the direct compression method and evaluate the powder and tablet properties of the ready-to-use excipients. Ready-to-use excipients, including Parteck® ODT, Kollitab™ DC 87 L, Ludiflash®, Ludipress® LCE, Parteck® M 200, Parteck® SI 150, Parteck® LUB MST were blended with Deferasirox. The blend consisting of eight different formulations was evaluated for powder properties, including angle of repose, bulk density, tapped density, Hausner's ratio, and compressibility index. The produced tablets were evaluated for tablet properties, including weight variation, breaking force, thickness, friability, disintegration test, and dissolution test. According to all the obtained results, none of the prepared formulations could fulfill the requirements needed to be applicable as an individual excipient of ODT. The formulations that could pass all the tests except the dissolution test were formulation (F5) Ludiflash® and formulation (F4) Kollitab™ DC 87 L. Ludiflash® could provide a drug release after 30 minutes of (45.62%) which was more than Kollitab™ DC 87 L which provides (35.32%). These excipients can not be used alone for ODTs. Further study is needed to optimize the formulations.