Shared and distinct lipid profiles in amygdala from sporadic and GBA-associated Parkinson’s diseases
cases. The levels of lipid classes and the relative proportion of lipid species affected in PD amygdala all correlated with glucocerebrosidase activity and/or pathological alpha-synuclein levels. The distinct lipid phenotypes observed across PD subgroups underscore the importance of patient stratification in clinical trials aiming at reverting PD-related lipid changes.
Authors
- Benjamin Dehay (ORCID: https://orcid.org/0000-0003-1723-9045)
- Céline Galvagnion
- Mesut Bilgin (ORCID: https://orcid.org/0000-0002-5034-8465)
- Katharina Schott
- Kenji Maeda
- Krista B. S. Neergaard
- Jesper E. Dreier
- Frederik R. Marlet
- Sonia S. Muñoz
- Erwan Bezard
- Zane Jaunmuktane
Institutions
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- University College London Hospitals NHS Foundation Trust (GB)
- Université de Bordeaux (FR)
- Institut des Maladies Neurodégénératives (FR)
- Danish Cancer Society (DK)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1038/s41531-026-01383-y
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Parkinsonforeningen
- Innovationsfonden
- Carlsbergfondet
- Lundbeckfonden
- Novo Nordisk Fonden
- Danmarks Frie Forskningsfond