Single-cell RNA-sequencing reveals cellular heterogeneity and identifies biomarkers for obstructive sleep apnea and migraine
BACKGROUND: Obstructive sleep apnea (OSA), a prevalent sleep disorder associated with migraine, has unclear effects on cellular heterogeneity within this comorbid context. RESULTS: T cells. CONCLUSION: Single-cell RNA analysis revealed a shared T cell-centered immune-dysregulated landscape in OSA and migraine, identifying common biomarkers and key pathways. These findings provide a crucial foundation for understanding comorbidities and developing new therapies.
Authors
- Lucong Liang
- Mika Pan (ORCID: https://orcid.org/0000-0002-8133-0241)
- Wenyi Song
- Tingting Cao (ORCID: https://orcid.org/0000-0001-6105-9960)
- Guining Liang
- Donghua Zou (ORCID: https://orcid.org/0009-0000-1907-3670)
- Youfeng Xie
- Qingyan Wei
- Rongjie Li
- Li Su
- Chun Zou
- Qipeng Cen
Institutions
- Guangxi Medical University (CN)
- Guangxi Minzu University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1186/s40246-026-00981-4
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00