Distinct Interplay Between β-Cell Function and Insulin Resistance in Latent Autoimmune Diabetes in Adults Versus Type 2 Diabetes

ARTICLE HIGHLIGHTS: The identification of differences in the relationship between insulin secretion and resistance among different diabetes types will help inform clinical decisions. The interplay between insulin secretion and resistance may distinguish latent autoimmune diabetes in adults (LADA) from type 2 diabetes. Individuals with LADA are less capable of mounting a sustained compensatory insulin secretion compared with those with type 2 diabetes, even at similar insulin resistance levels. Distinct pathophysiology characterizes LADA and type 2 diabetes. The defect in insulin secretion for similar levels of insulin resistance might contribute to the higher risk of poor glycemic control often observed in LADA, arguing for accurate diagnosis of adult-onset diabetes types.