Form (III) of artemisinin: discovery and crystallographic characterization of a new high-pressure polymorph
screw axis in form (III), resulting in a change from triclinic to monoclinic and a reduction of the asymmetric unit from Z' = 4 to Z' = 2. These findings contribute to a deeper understanding of pressure-induced polymorphism in ART and underscores the importance of external factors such as PTM in influencing solid-state transitions relevant to pharmaceutical processing and formulation.
Authors
- C.L. Doherty (ORCID: https://orcid.org/0000-0003-0859-0116)
- Mark R. Warren (ORCID: https://orcid.org/0000-0003-1326-0744)
- Banaz Fetah
- Iain D. H. Oswald
- Lauren E. Connor
Institutions
- University of Strathclyde (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Age UK (GB)
- Diamond Light Source (GB)
- GlaxoSmithKline (Ireland) (IE)
Publication Details
- Journal
- Acta Crystallographica Section B Structural Science Crystal Engineering and Materials
- Published
- 2026-04-29
- DOI
- https://doi.org/10.1107/s205252062600291x
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00