Concept-Enhanced Multimodal RAG: Towards Interpretable and Accurate Radiology Report Generation

Abstract Radiology Report Generation (RRG) through Vision-Language Models (VLMs) promises to reduce documentation burden, improve reporting consistency, and accelerate clinical workflows. However, their clinical adoption remains limited by the lack of interpretability and the tendency to hallucinate findings misaligned with imaging evidence. Existing research typically treats interpretability and accuracy as separate objectives, with concept-based explainability techniques focusing primarily on transparency, while Retrieval-Augmented Generation (RAG) methods targeting factual grounding through external retrieval. We present Concept-Enhanced Multimodal RAG ( CEMRAG ), a unified framework that decomposes visual representations into interpretable clinical concepts and integrates them with multimodal RAG. This approach exploits enriched contextual prompts for RRG, improving both interpretability and factual accuracy. Experiments on MIMIC-CXR and IU X-Ray across multiple VLM architectures, training regimes, and retrieval configurations demonstrate consistent improvements over both conventional RAG and concept-only baselines on clinical accuracy metrics and standard NLP measures. These results challenge the assumed trade-off between interpretability and performance, showing that transparent visual concepts can enhance rather than compromise diagnostic accuracy in medical VLMs. Our modular design decomposes interpretability into visual transparency and structured language model conditioning, providing a principled pathway toward clinically trustworthy AI-assisted radiology. The project page is available at https://github.com/marcosal30/cemrag-rrg .

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Publication Details

Journal
Information Systems Frontiers
Published
2026-05-11
DOI
https://doi.org/10.1007/s10796-026-10741-3
Primary Topic
Multimodal Machine Learning Applications
Type
article
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article

Concept-Enhanced Multimodal RAG: Towards Interpretable and Accurate Radiology Report Generation

Rosa Sicilia, Federico Siciliano, Marco Salmè, Fabrizio Silvestri et al.
Information Systems Frontiers
Multimodal Machine Learning Applications
article

Concept-Enhanced Multimodal RAG: Towards Interpretable and Accurate Radiology Report Generation

Rosa Sicilia, Federico Siciliano, Marco Salmè, Fabrizio Silvestri, Valerio Guarrasi, Paolo Soda
article en

Abstract

Abstract Radiology Report Generation (RRG) through Vision-Language Models (VLMs) promises to reduce documentation burden, improve reporting consistency, and accelerate clinical workflows. However, their clinical adoption remains limited by the lack of interpretability and the tendency to hallucinate findings misaligned with imaging evidence. Existing research typically treats interpretability and accuracy as separate objectives, with concept-based explainability techniques focusing primarily on transparency, while Retrieval-Augmented Generation (RAG) methods targeting factual grounding through external retrieval. We present Concept-Enhanced Multimodal RAG ( CEMRAG ), a unified framework that decomposes visual representations into interpretable clinical concepts and integrates them with multimodal RAG. This approach exploits enriched contextual prompts for RRG, improving both interpretability and factual accuracy. Experiments on MIMIC-CXR and IU X-Ray across multiple VLM architectures, training regimes, and retrieval configurations demonstrate consistent improvements over both conventional RAG and concept-only baselines on clinical accuracy metrics and standard NLP measures. These results challenge the assumed trade-off between interpretability and performance, showing that transparent visual concepts can enhance rather than compromise diagnostic accuracy in medical VLMs. Our modular design decomposes interpretability into visual transparency and structured language model conditioning, providing a principled pathway toward clinically trustworthy AI-assisted radiology. The project page is available at https://github.com/marcosal30/cemrag-rrg .

Information Systems Frontiers
Openalex Percentile: Top 6%
Multimodal Machine Learning Applications
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Concept-Enhanced Multimodal RAG: Towards Interpretable and Accurate Radiology Report Generation — Rosa Sicilia, Federico Siciliano, et al. · Information Systems Frontiers (2026) | TGRS Research Map | TGRS