Mining Cytochrome P450 Enzymes Involved in Casbene Oxidation from <i>Euphorbia fischeriana</i> Steud. and Clarifying Their Substrate Specificity
-hydroxylation as previously reported. Moreover, the CYP orthologues (e.g., casbene-5,6-oxidases EfCYP726A47 and ElCYP726A27) involved in casbene oxidation in Euphorbiaceae may possess different substrate specificity. Overall, this study expands the enzymatic tools for casbene oxidation and exhibits the complexity of casbene-related diterpenoid biosynthesis.
Authors
- Lan Bu (ORCID: https://orcid.org/0000-0002-4358-6174)
- Ke Gao (ORCID: https://orcid.org/0000-0002-2865-2073)
- Jianxun Zhu (ORCID: https://orcid.org/0000-0003-4285-7101)
- L Zhao
- Pengcheng Lin
- Jiachen Zi (ORCID: https://orcid.org/0000-0002-0212-1282)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qinghai University for Nationalities (CN)
- Key Laboratory of Guangdong Province (CN)
- Qinghai Tibetan Hospital (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00168
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences