Forward–Backward-Flushing Valve-Assisted Selectivity Tuning (FBF-VAST) for LC × LC: Principles and Demonstration of a Modulation Mechanism
D-column cleaning, which may extend column life and improve robustness. This cost-effective and tunable LC × LC strategy offers enhanced control over chromatographic selectivity and long-term stability, all within a simplified instrumental design.
Authors
- Chadin Kulsing (ORCID: https://orcid.org/0000-0003-0348-1746)
- Sornkanok Vimolmangkang (ORCID: https://orcid.org/0000-0002-1705-6217)
- Pattraporn Chobpradit
- Kenji Hamase (ORCID: https://orcid.org/0000-0001-6140-4787)
- Thumnoon Nhujak (ORCID: https://orcid.org/0000-0002-6362-2400)
Institutions
- Kyushu University (JP)
- Chulalongkorn University (TH)
- Tellabs (Canada) (CA)
- Netherlands Metabolomics Centre (NL)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1021/acs.analchem.5c08280
- Primary Topic
- Analytical Chemistry and Chromatography
- Type
- article
- Field-Weighted Citation Impact
- 0.00