Structural optimization of CHI3L1 inhibitors with improved pharmacokinetics and functional activity in 3D glioblastoma models

as a CHI3L1 inhibitor with a superior pharmacokinetic profile and robust functional activity, marking it as a promising candidate for further GBM drug development.

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Publication Details

Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Published
2026-05-11
DOI
https://doi.org/10.1080/14756366.2026.2668243
Primary Topic
Studies on Chitinases and Chitosanases
Type
article
Field-Weighted Citation Impact
0.00

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article

Structural optimization of CHI3L1 inhibitors with improved pharmacokinetics and functional activity in 3D glioblastoma models

Moustafa Gabr, Hossam Nada, Baljit Kaur
Journal of Enzyme Inhibition and Medicinal Chemistry
Studies on Chitinases and Chitosanases
article

Structural optimization of CHI3L1 inhibitors with improved pharmacokinetics and functional activity in 3D glioblastoma models

Moustafa Gabr, Hossam Nada, Baljit Kaur
article en

Abstract

as a CHI3L1 inhibitor with a superior pharmacokinetic profile and robust functional activity, marking it as a promising candidate for further GBM drug development.

Journal of Enzyme Inhibition and Medicinal ChemistryVol. 41(1)
Molecular Innovations (United States) (US)
National Institute of Neurological Disorders and Stroke
Openalex Percentile: Top 9%
Studies on Chitinases and Chitosanases
DOIOpen Access PDFOpenAlex
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Structural optimization of CHI3L1 inhibitors with improved pharmacokinetics and functional activity in 3D glioblastoma models — Moustafa Gabr, Hossam Nada, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry (2026) | TGRS Research Map | TGRS