Recent Advances in Nickel Catalysts for Sonogashira Coupling

The Sonogashira coupling, catalyzed by transition metals, has become a valuable method for forming carbon-carbon bonds. While palladium-copper was originally recognized as the most effective catalyst for this transformation, recent advances have highlighted the growing prominence of nickel-catalyzed Sonogashira reactions. Nickel has gained considerable interest due to its lower cost and more environmentally friendly profile compared to palladium. This review focuses on recent progress in nickel-catalyzed Sonogashira coupling, surveying studies published between 2021 and 2025.