Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction
) for 1 week recapitulated key pathological features, including structural remodeling and a dysregulated secretome with altered vascular endothelial growth factor signaling. This approach establishes a versatile and human-relevant platform to study microvascular remodeling induced by chronic hypoxia and other pathological stimuli and their contribution to microvascular-related diseases.
Authors
- Paola Serrano Martinez (ORCID: https://orcid.org/0000-0002-0688-0083)
- Maxime Cammeraat
- Ingeborg Klaassen (ORCID: https://orcid.org/0000-0003-1695-9403)
- C J Van Noorden
- R.O. Schlingemann
- Amber Teppema
Institutions
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Histochemistry & Cytochemistry
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1369/00221554261437861
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Steunfonds Uitzicht
- Diabetes Fonds