Modulation of BK-like potassium currents by ketamine in rat cochlear outer hair cells
channel activity rather than direct α9α10 nicotinic receptor-mediated currents. Therefore, the present experimental design does not allow determination of whether ketamine directly affects α9α10 receptor function. These findings demonstrate that ketamine modulates BK-like potassium currents in OHCs and may influence cochlear electrophysiological function. However, the precise mechanism-whether through direct channel interaction or indirect modulation via calcium signaling-remains to be determined.
Authors
- Xuerong Zhang (ORCID: https://orcid.org/0000-0003-1898-6771)
- Jingrun Lin (ORCID: https://orcid.org/0000-0002-7465-9938)
- Xueying Yang (ORCID: https://orcid.org/0009-0000-1787-7229)
- Y Xu
- Qiong Zhao
- Yanan Lu
- Fengtao Ji
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Molecular Brain
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1186/s13041-026-01306-1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University