Diverse paths to broadly neutralizing antibody escape among HIV-1 strains
. Some 3BNC117 resistance mutations conferred resistance to additional bnAbs targeting the same or different epitopes, and unconventional escape mechanisms were occasionally encountered. These data provide a rationale for selecting bnAb combinations that are most likely to achieve treatment success.
Authors
- Alex C. Stabell
- Christy L. Lavine (ORCID: https://orcid.org/0000-0001-6135-0547)
- Viren A. Baharani (ORCID: https://orcid.org/0009-0009-2011-9547)
- Théodora Hatziioannou (ORCID: https://orcid.org/0000-0002-7889-0766)
- Michael S. Seaman (ORCID: https://orcid.org/0000-0001-6444-3562)
- Songhee lee
- Rachel Patejak (ORCID: https://orcid.org/0009-0006-2739-9228)
- Michel C. Nussenzweig (ORCID: https://orcid.org/0000-0003-0592-8564)
- Sebastian Mejia Espinosa
- Marina Caskey (ORCID: https://orcid.org/0000-0003-1727-8693)
- Debby J. Park (ORCID: https://orcid.org/0000-0002-1029-7253)
- Paul D. Bieniasz (ORCID: https://orcid.org/0000-0002-2368-3719)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Howard Hughes Medical Institute (US)
- Cornell University (US)
- Rockefeller University (US)
Publication Details
- Journal
- Nature Microbiology
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1038/s41564-026-02347-x
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Howard Hughes Medical Institute
- National Institutes of Health