Evaluation of surgical stress after colorectal interventions: a multicenter randomized clinical trial of robotic versus laparoscopic surgery
A major factor in the development of morbidity after surgery is the surgical stress response. The aim of this interventional multicenter randomized open label, parallel group trial is to evaluate the possible lower inflammatory stress response induced by robot-assisted versus laparoscopic surgery for colorectal resections. A total of 593 patients diagnosed with colorectal cancer planned for elective, curative surgery was screened for eligibility. 314 patients planned for right colectomy, left colectomy or rectal resection were randomly assigned 1:1 to robotic (n = 161) or laparoscopic group (n = 153). The primary endpoint was the 24-hours postoperative ∆% change of IL-6 serum levels. Subgroup analyses included the assessment of IL-6 ∆% changes stratified according to age, obesity, comorbidities, tumor staging and resection type have been also performed. In conclusion robotic surgery was associated to a lower surgical stress after colorectal surgery and this finding may help in decision-making regarding when to proceed to robotic approach for colorectal cancer, especially in selected high risk clinical settings.
Authors
- Daniela Rega (ORCID: https://orcid.org/0000-0001-8326-050X)
- Michele Manigrasso (ORCID: https://orcid.org/0000-0001-8204-7942)
- Monica Ortenzi (ORCID: https://orcid.org/0000-0002-6508-6488)
- Gregory Alexander Raciti (ORCID: https://orcid.org/0000-0003-2742-5634)
- Matteo Nicola Dario Di Minno (ORCID: https://orcid.org/0000-0001-8059-3819)
- Michele Campitelli (ORCID: https://orcid.org/0000-0001-7592-5022)
- Uberto Fumagalli
- Felice Pirozzi (ORCID: https://orcid.org/0000-0002-6385-5394)
- Fabio Rondelli
- Rossella Reddavid (ORCID: https://orcid.org/0000-0003-0603-9953)
- Antonio Sciuto (ORCID: https://orcid.org/0000-0003-3234-4580)
- Pietro Anoldo (ORCID: https://orcid.org/0000-0001-6727-2973)
- Lucia Puca (ORCID: https://orcid.org/0000-0003-3963-3377)
- Antonella Desiderio (ORCID: https://orcid.org/0000-0002-3510-7663)
- Anna D’Amore (ORCID: https://orcid.org/0000-0003-1264-4295)
- Fatima Domenica Elisa De Palma (ORCID: https://orcid.org/0000-0002-6109-2768)
- Simona Borin (ORCID: https://orcid.org/0000-0001-7463-723X)
- Graziano Ceccarelli (ORCID: https://orcid.org/0000-0002-7859-6815)
- Sara Vertaldi (ORCID: https://orcid.org/0000-0001-9633-9575)
- Wanda Petz
- Giovanni Domenico De Palma
- Maurizio Degiuli
- Ugo Pace
- Ilenia Calcaterra
- Mario Guerrieri
- Marco Milone
- Paolo Delrio
Institutions
- Marche Polytechnic University (IT)
- University of Perugia (IT)
- Ospedale Antonio Cardarelli (IT)
- Azienda Ospedaliero Universitaria San Giovanni Battista (IT)
- Fatebenefratelli Hospital (IT)
- Federico II University Hospital (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Ospedale San Luigi Gonzaga (IT)
- University of Turin (IT)
- European Institute of Oncology (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1038/s41598-026-51855-7
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00