Identification of an Hsp110/HDAC6 Dual-Target Inhibitor for the Effective Treatment of Pulmonary Arterial Hypertension via Synergistic Blockade of Vascular Remodeling
demonstrated enhanced suppressive effects on vascular remodeling through synchronous regulation of dual targets. In summary, the present study provides novel research insights into developing novel PAH drugs based on antivascular remodeling strategies and offers a promising lead compound.
Authors
- Liqing Hu (ORCID: https://orcid.org/0000-0003-3592-488X)
- S. Xiang
- Congke Zhao
- Y Hu
- Qi Li (ORCID: https://orcid.org/0000-0001-8776-8730)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Mengqi Li (ORCID: https://orcid.org/0000-0003-3894-5651)
- Wenhua Tan
- Ruizhe Gao
- Xinru Liang
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-5434-5747)
Institutions
- Central South University (CN)
- Hunan University (CN)
- Hunan Normal University (CN)
- Discovery Centre (CA)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00066
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province