Enabling Base‐Free Direct C–H Arylation of Thiophene Derivatives: Glycerol‐Derived Solvents as Active Reaction Media
Nonvolatile glycerol derivatives are employed as effective reaction media for the Pd-catalysed direct CH arylation of 3,4-ethylenedioxythiophene and other thiophenes. The thoughtful design of noninnocent glycerol-derived ionic liquids (ILs) allows them to act simultaneously both as solvent and base, eliminating the need for an additional base and thus improving the sustainability of the process. Moreover, the stabilization of palladium nanoparticles in the task-specific solvent offers an excellent approach by providing the advantages of a homogeneous, selective, and recoverable catalytic system. This multifunctional behaviour highlights the potential of glycerol-derived ILs as sustainable solvents and promoters for transition metal-catalysed CH activation reactions.
Authors
- Claudia Barolo (ORCID: https://orcid.org/0000-0003-0627-2579)
- Alessandra Sanson (ORCID: https://orcid.org/0000-0001-8519-282X)
- Elísabet Pires (ORCID: https://orcid.org/0000-0002-2676-8814)
- Matteo Bonomo (ORCID: https://orcid.org/0000-0002-1944-2664)
- Sara Gracia-Barberán (ORCID: https://orcid.org/0000-0003-2955-3509)
- Stefano Nejrotti (ORCID: https://orcid.org/0000-0002-6017-5705)
- José A. Mayoral
- Alejandro Leal‐Duaso (ORCID: https://orcid.org/0000-0002-3256-2089)
Institutions
- Universidad de Zaragoza (ES)
- Instituto de Síntesis Química y Catálisis Homogénea (ES)
- Institute of Science and Technology for Ceramics (IT)
- Torino e-district (IT)
- National Interuniversity Consortium of Materials Science and Technology (IT)
- University of Turin (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- ChemSusChem
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1002/cssc.202502519
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00