Integrated transcriptomic and proteomic analysis reveals inflammatory activation and blood-brain barrier disruption during meningitis-associated extraintestinal pathogenic <i>Escherichia coli</i> infection
experiments demonstrated RS218-induced cell death in brain endothelial cells, microglial cells, and peritoneal macrophages. Animal experiments confirmed systemic metabolic disruption, immune cell alteration, functional BBB disruption, and profound brain cytokine elevation. This integrated analysis advances our understanding of bacterial meningitis pathogenesis and identifies potential therapeutic targets.
Authors
- Yangyang Du (ORCID: https://orcid.org/0000-0003-3914-2690)
- Xiaoying Yu (ORCID: https://orcid.org/0000-0003-1659-2365)
- Lianci Peng (ORCID: https://orcid.org/0000-0002-9005-3186)
- Meili Chen
- Z Li
- Xuefeng Cao (ORCID: https://orcid.org/0000-0002-9950-8503)
- Yi Lu
- Kaixiang Jia
- Rendong Fang (ORCID: https://orcid.org/0000-0003-3094-5059)
Institutions
- Southwest University (CN)
- Stanford University (US)
Publication Details
- Journal
- Virulence
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1080/21505594.2026.2670939
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Science and Technology Commission
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities