Artificial Intelligence Chatbots for Dysphagia Patient Education: A Multi‐Center International Expert Evaluation
BACKGROUND: Patients increasingly consult artificial intelligence (AI) chatbots for health information, yet the reliability and accessibility of AI-generated content for complex conditions like dysphagia remain unvalidated. We conducted the first head-to-head comparison of leading large language models for dysphagia patient education, evaluated by an international expert panel. METHODS: Forty-six validated questions across four clinical domains were submitted to ChatGPT-4.0 (OpenAI) and Claude 3.7 (Anthropic) in March 2025. Ten blinded experts from six countries rated responses for scientific accuracy (5-point Likert), clarity (5-point Likert), and misinformation (binary). Readability was assessed using Flesch Reading Ease, Flesch-Kincaid Grade Level, and SMOG Index. Between-model comparisons used Wilcoxon signed-rank tests with Cohen's d effect sizes. KEY RESULTS: No significant differences emerged for scientific accuracy (ChatGPT: 3.87 ± 0.36 vs. Claude: 3.93 ± 0.35; p = 0.26; d = 0.16), clarity (4.12 ± 0.34 vs. 4.15 ± 0.27; p = 0.67; d = 0.11), or mean misinformation rates (both 2.15; p = 0.96). Strong inter-model correlation existed for accuracy (rs = 0.678; p < 0.001). Critically, both models produced content far exceeding recommended readability levels: SMOG indices of 14.95 ± 2.40 years (ChatGPT) and 17.37 ± 2.67 years (Claude) required extensive education (p < 0.001; d = 0.95) versus the recommended 6-7 years. Categorical analysis showed Claude generated three times more misinformation-free responses (19.6% vs. 6.5%; p = 0.077). CONCLUSIONS AND INFERENCES: Leading AI chatbots demonstrate equivalent, acceptable accuracy for dysphagia information but produce content inaccessible to most patients due to excessive complexity. The strong inter-model correlation suggests shared limitations in medical training data. Before clinical implementation, AI-generated patient education requires mandatory readability optimization to address the substantial health literacy gap identified in this study.
Authors
- Luisa Bertin (ORCID: https://orcid.org/0009-0001-9816-4171)
- Jerome Rene Lechien (ORCID: https://orcid.org/0000-0002-0845-0845)
- Amir Mari (ORCID: https://orcid.org/0000-0002-6828-4738)
- Sílvia Carrión (ORCID: https://orcid.org/0000-0002-1354-2488)
- CP Gyawali
- E V Savarino
- John Clarke
- Ram Dickman
- Afrin K. Rahman (ORCID: https://orcid.org/0000-0001-8950-8916)
- Elisa Marabotto
- Vincenzo Savarino
- Sabine Roman (ORCID: https://orcid.org/0000-0002-7798-7638)
- Frank Zerbib (ORCID: https://orcid.org/0000-0002-6802-2121)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Padua (IT)
- Bar-Ilan University (IL)
- Université de Bordeaux (FR)
- Inserm (FR)
- Washington University in St. Louis (US)
- Nazareth Hospital EMMS (IL)
- Rabin Medical Center (IL)
- Instituto de Salud Carlos III (ES)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Université de Poitiers (FR)
- Hospices Civils de Lyon (FR)
- Bordeaux Population Health (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Hospital de Mataró (ES)
- Ospedale Policlinico San Martino (IT)
- Azienda Ospedale - Università Padova (IT)
- University of Genoa (IT)
- Stanford University (US)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/nmo.70344
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 0.00