FTO Controls Endometrial Receptivity and Embryo Implantation through Regulating m6A and H3K27me3
A on SUZ12 mRNA, lowering its stability, weakening PRC2 function and de-repressing WNT5B. Functionally, FTO depletion impaired spheroid adhesion and Wnt signaling, reversible by SUZ12 restoration or WNT5B inhibition. Thus, FTO preserves epithelial integrity and endometrial receptivity by stabilizing SUZ12 mRNA and maintaining H3K27me3 mediated repression of WNT5B, implicating the FTO/SUZ12/WNT5B axis in implantation failure.
Authors
- Boxian Huang (ORCID: https://orcid.org/0000-0001-9913-9077)
- Qingxia Meng (ORCID: https://orcid.org/0009-0005-0666-7425)
- Fengjia Guo
- Linlin Tan
- Hong Li
- Wenjuan Xia
- Xiujuan Hu
- Jincheng Li
- Ming Zhang
- Jiafeng Lu
Institutions
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Communications Biology
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1038/s42003-026-10247-3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China