Combining Oxygen‐Enhanced <scp>MRI</scp> and Electron Paramagnetic Resonance Oximetry for Quantitative <scp>OE</scp> ‐ <scp>MRI</scp> ( <scp>qOE</scp> ‐ <scp>MRI</scp> ) as a Method for Mapping Absolute Oxygen Levels ( <scp> pO <sub>2</sub> </scp> )
PURPOSE: . METHODS: maps. RESULTS: maps revealed marked intratumoral heterogeneity: the hypoxic core on average showed no increase in oxygenation due to hyperoxygenation, whereas peripheral and muscle-adjacent regions exhibited increased oxygenation. CONCLUSION: mapping. By combining OxyChip technology, clinical EPR systems, and standard MRI platforms, this approach holds promise for translation into hypoxia-guided radiation therapy planning.
Authors
- Periannan Kuppusamy (ORCID: https://orcid.org/0000-0002-3214-0660)
- Philip E. Schaner (ORCID: https://orcid.org/0000-0002-5239-1950)
- Diana J. Wallin (ORCID: https://orcid.org/0000-0003-4244-0314)
- Sergey Petryakov
- Alireza Kheirollah (ORCID: https://orcid.org/0000-0002-8235-8190)
- Conner S. Ubert
- Ryan C. O'Connell
- Maciej M. Kmiec
- Victor B. Kassey
Institutions
- Dartmouth College (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/mrm.70418
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00