Stool microbial composition is associated with recent and future diarrhea and fever events in breastfed Danish infants
in well-nourished, breastfeeding Danish infants, as it is in children from low-income countries, and that the early gut microbiome may contribute to risks of diarrhea and fever morbidities later in infancy.CLINICAL TRIALSThis trial was registered at ClinicalTrials.gov as NCT03254329. IMPORTANCE: ) and mutualists (bifidobacteria), which may have contributed to fever differently-pathobionts through infection and mutualists through promotion of effective immune response to infection.
Authors
- Sarah S Spearman
- David H. Storms
- Laurynne C. Coates (ORCID: https://orcid.org/0000-0002-8325-107X)
- Sophie Hilario Christensen (ORCID: https://orcid.org/0000-0001-9592-0376)
- Danielle G. Lemay (ORCID: https://orcid.org/0000-0003-3318-0485)
- Christian Mølgaard (ORCID: https://orcid.org/0000-0002-5311-9457)
- Mary E. Kable (ORCID: https://orcid.org/0000-0002-5485-6539)
- Lindsay H. Allen (ORCID: https://orcid.org/0000-0002-8729-5213)
- Kim F. Michaelsen
- Jack I. Lewis
- Setareh Shahab-Ferdows
Institutions
- United States Department of Agriculture (US)
- Western Human Nutrition Research Center (US)
- Nutrition Sciences (Belgium) (BE)
- University of California, Davis (US)
Publication Details
- Journal
- mSystems
- Published
- 2026-05-11
- DOI
- https://doi.org/10.1128/msystems.00134-26
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Agricultural Research Service