Copper-Catalyzed Regioselective [4 + 1 + 1] Annulation to 1,2-Oxazines Using Dioxazolones and H <sub>2</sub> O as the Heteroatom Sources

O) to build molecular complexity. This method features mild conditions, exclusive regioselectivity, and broad functional group compatibility, offering a modular alternative to traditional nitroso Diels-Alder (NDA) chemistry.

Authors

Lu Xu (ORCID: https://orcid.org/0009-0007-6287-6832)
Liuxin Luo
Tiankui Huang
Yu Wei (ORCID: https://orcid.org/0000-0002-4432-7190)
Shuai Liu (ORCID: https://orcid.org/0000-0003-1625-3566)
Liang Xu (ORCID: https://orcid.org/0000-0002-7939-8108)
Huanhuan Song (ORCID: https://orcid.org/0009-0001-5447-8857)

Institutions

Shihezi University (CN)
Silicon Chemical (United States) (US)

Publication Details

Journal: Organic Letters
Published: 2026-05-11
DOI: https://doi.org/10.1021/acs.orglett.6c01526
Primary Topic: Catalytic C–H Functionalization Methods
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Shihezi University

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article

Copper-Catalyzed Regioselective [4 + 1 + 1] Annulation to 1,2-Oxazines Using Dioxazolones and H ₂ O as the Heteroatom Sources

Lu Xu, Liuxin Luo, Tiankui Huang, Yu Wei et al.

May 11, 2026

Organic Letters

Catalytic C–H Functionalization Methods

article

Copper-Catalyzed Regioselective [4 + 1 + 1] Annulation to 1,2-Oxazines Using Dioxazolones and H ₂ O as the Heteroatom Sources

Lu Xu, Liuxin Luo, Tiankui Huang, Yu Wei, Shuai Liu, Liang Xu, Huanhuan Song

May 11, 2026article en

Abstract

O) to build molecular complexity. This method features mild conditions, exclusive regioselectivity, and broad functional group compatibility, offering a modular alternative to traditional nitroso Diels-Alder (NDA) chemistry.

Organic Letters

Shihezi University (CN), Silicon Chemical (United States) (US)

Shihezi University

Openalex Percentile: Top 10%

Catalytic C–H Functionalization Methods

DOI Source OpenAlex

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Copper-Catalyzed Regioselective [4 + 1 + 1] Annulation to 1,2-Oxazines Using Dioxazolones and H <sub>2</sub> O as the Heteroatom Sources — Lu Xu, Liuxin Luo, et al. · Organic Letters (2026) | TGRS Research Map | TGRS