Exosome‐Delivered <scp>eNAMPT</scp> From Exercise Activates <scp>SIRT1</scp> to Counteract Age‐Related Hepatic Steatosis and Fibrosis
-SIRT1 cascade. Collectively, our results elucidate a novel exosome-mediated pathway through which exercise mitigates age-related liver disease, positioning exosomal eNAMPT as a promising therapeutic agent and exercise mimetic for MASLD.
Authors
- Zhiwei Yue (ORCID: https://orcid.org/0000-0002-7579-148X)
- Jiaqi Li (ORCID: https://orcid.org/0000-0002-2201-8290)
- Naijun Wu
- Yajuan QI
- Xuefeng Zhu (ORCID: https://orcid.org/0000-0002-4759-4446)
- Wenxuan Song
- S H Liu
- X Li
- Dan Li
- Qiang Ma
Institutions
- North China University of Science and Technology (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/acel.70541
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00