Recruitment Strategies across the Spectrum of Neuronal Synuclein Disease

The Parkinson's Progression Markers Initiative (PPMI) has remained at the vanguard of Parkinson's disease (PD) research through evolving recruitment strategies that mirror advances in PD biology. PPMI was initially focused on untreated, early-stage PD. Over time, it has expanded to include genetic cohorts, prodromal participants identified via olfactory testing and risk factor questionnaires targeting people with rapid eye movement (REM) sleep behavior disorder (RBD). Most recently, PPMI has focused on the biology underlying PD and sought to recruit individuals defined by neuronal alpha-synuclein disease (NSD) biomarkers. This evolution from clinical to biological enrollment demonstrates the feasibility of biomarker-driven cohort design and establishes a scalable model for early detection and prevention research in neurodegenerative disease. ANN NEUROL 2026.

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Publication Details

Journal
Annals of Neurology
Published
2026-05-10
DOI
https://doi.org/10.1002/ana.78239
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Recruitment Strategies across the Spectrum of Neuronal Synuclein Disease

Emily Flagg, Bridget A. McMahon, Kimberly Fabrizio, Erinn Bryan et al.
Annals of Neurology
Parkinson's Disease Mechanisms and Treatments
article

Recruitment Strategies across the Spectrum of Neuronal Synuclein Disease

Emily Flagg, Bridget A. McMahon, Kimberly Fabrizio, Erinn Bryan, Laura E. A. Heathers, Lynell P. Lemon, Neha Prakash, Kenneth Marek, Michelle Totten, Nicola Pavese, Caroline M. Tanner, Audra Bright, the Parkinson's Progression Markers Initiative, Andrew Siderowf, Christopher S. Coffey, Tanya Simuni, Anat Mirelman, Sohini Chowdhury, Maggie McGuire Kuhl, Eduardo Tolosa, Njideka Okubadejo, Tatiana Foroud, Catherine M. Kopil, Leonidas Stefanis, Bastiaan R. Bloem, Thomas F. Tropea, Roy N. Alcalay
article en

Abstract

The Parkinson's Progression Markers Initiative (PPMI) has remained at the vanguard of Parkinson's disease (PD) research through evolving recruitment strategies that mirror advances in PD biology. PPMI was initially focused on untreated, early-stage PD. Over time, it has expanded to include genetic cohorts, prodromal participants identified via olfactory testing and risk factor questionnaires targeting people with rapid eye movement (REM) sleep behavior disorder (RBD). Most recently, PPMI has focused on the biology underlying PD and sought to recruit individuals defined by neuronal alpha-synuclein disease (NSD) biomarkers. This evolution from clinical to biological enrollment demonstrates the feasibility of biomarker-driven cohort design and establishes a scalable model for early detection and prevention research in neurodegenerative disease. ANN NEUROL 2026.

Annals of Neurology
Northwestern University (US), University of Iowa (US), Radboud University Nijmegen (NL), Tel Aviv University (IL), University of California, San Francisco (US), University of Lagos (NG), National and Kapodistrian University of Athens (GR), Columbia University Irving Medical Center (US), Tel Aviv Sourasky Medical Center (IL), Michael J. Fox Foundation (US), Radboud University Medical Center (NL), Institute for Neurodegenerative Disorders (US), NIHR Newcastle Biomedical Research Centre (GB), Elucid Bioimaging (US), Newcastle Hospitals - Campus for Ageing and Vitality (GB), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Indiana University – Purdue University Indianapolis (US), University of Pennsylvania (US), Newcastle University (GB)
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Openalex Percentile: Top 5%
Parkinson's Disease Mechanisms and Treatments
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