“Extraction, Development, and <i>Ex-Vivo</i> Evaluation of Thermoresponsive Mucoadhesive <i>In-Situ</i> Nasal Gel Incorporating <i>Lablab purpureus</i> Mucilage and Pluronic F127 for Enhanced Intranasal Delivery of Diclofenac Sodium”

OBJECTIVE: mucilage with Pluronic F127 yields a stable, mucoadhesive gel enhancing Diclofenac nasal delivery. METHODS: release, permeation, kinetic modeling, six-month stability, and histopathological safety on goat nasal mucosa were also assessed. RESULTS: , with drug content 87.8 ± 0.3 to 97.7 ± 0.8%. FA6 exhibited 95.8% release and 96.8% permeation following First-Order kinetics, while FB6 followed the Korsmeyer-Peppas model. CONCLUSIONS: FA6 demonstrated optimal mucoadhesion, permeation, and stability, confirming strong potential as an effective thermoresponsive nasal delivery system for Diclofenac Sodium.