Synthesis of Novel <i>C</i> ‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling

We developed an efficient methodology for synthesizing C ‐acyl‐glycosyl sulfonamides via a carbonylative coupling reaction, using 1‐iodo‐glycals as substrates. A wide range of aromatic, heteroaromatic, and aliphatic sulfonamides was explored, employing Mo(CO) 6 as a safe, solid source of carbon monoxide gas. This approach enabled the preparation of novel glycosyl sulfonamides featuring a C ‐acyl‐linked framework under mild reaction conditions, achieving good to excellent yields.