The role of vitamin C as potent antioxidant and pro-oxidation in acute myeloid leukemia treatment progress

Vitamin C has effects cancer in both antioxidant and pro-oxidant. It serves as an antioxidant by reducing oxidative stressors and minimizing genetic damage. Conversely, high pharmacological doses of vitamin C can act as pro-oxidant impacts that are detrimental to cancerous cells. moreover, vitamin C can modify the metabolomics and epigenetic profiles of cancer cells, leading to the elimination of cancer stem cells. Additionally, it can enhance immune system activity and suppress cancer transformation through various pathways. The study included a review of several studies that dealt with the effect of vitamin C on leukemia patients or associated it with treatment in vitro or in vivo to enhance patient’s response to treatment and minimize side effects. It has been shown through previous and recent studies that the role of vitamin C is effective in treating leukemia patients. Additional researches are required to better understand the mechanistic and clinical dimensions of these effects.