Recent Advances in the Synthesis of Chromeno[4,3‐ <i>b</i> ]pyrrolidines

Chromeno[4,3‐ b ]pyrrolidine derivatives are a class of compounds featuring a unique tricyclic fused scaffold and exhibiting significant biological activities. In recent years, remarkable progress has been made in developing efficient synthetic strategies for these complex structures. This review aims to systematically summarize various methods for synthesizing chromeno[4,3‐ b ]pyrrolidine derivatives. Based on the type of catalyst employed, we have summarized and categorized four main catalytic strategies: Brønsted base catalysis, N ‐heterocyclic carbene catalysis, phosphine catalysis, and metal catalysis. The cyclization strategies and their proposed reaction mechanisms are discussed in detail, and we believe this review will provide valuable inspiration for future innovative research in this field.

Authors

Institutions

Publication Details

Journal
European Journal of Organic Chemistry
Published
2026-05-09
DOI
https://doi.org/10.1002/ejoc.70535
Primary Topic
Catalytic Cross-Coupling Reactions
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Recent Advances in the Synthesis of Chromeno[4,3‐ b ]pyrrolidines

Bingjie Li, Yan Gao, Er‐Qing Li, Li Li et al.
European Journal of Organic Chemistry
Catalytic Cross-Coupling Reactions
article

Recent Advances in the Synthesis of Chromeno[4,3‐ b ]pyrrolidines

Bingjie Li, Yan Gao, Er‐Qing Li, Li Li, Yue Wang
article en

Abstract

Chromeno[4,3‐ b ]pyrrolidine derivatives are a class of compounds featuring a unique tricyclic fused scaffold and exhibiting significant biological activities. In recent years, remarkable progress has been made in developing efficient synthetic strategies for these complex structures. This review aims to systematically summarize various methods for synthesizing chromeno[4,3‐ b ]pyrrolidine derivatives. Based on the type of catalyst employed, we have summarized and categorized four main catalytic strategies: Brønsted base catalysis, N ‐heterocyclic carbene catalysis, phosphine catalysis, and metal catalysis. The cyclization strategies and their proposed reaction mechanisms are discussed in detail, and we believe this review will provide valuable inspiration for future innovative research in this field.

European Journal of Organic Chemistry
Shantou University (CN), Henan University of Technology (CN), Zhengzhou University (CN), Jiaozuo University (CN), First Affiliated Hospital of Shantou University Medical College (CN)
Natural Science Foundation of Henan Province
Industry, innovation and infrastructure
Openalex Percentile: Top 9%
Catalytic Cross-Coupling Reactions
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.