Recent Advances in the Synthesis of Chromeno[4,3‐ <i>b</i> ]pyrrolidines
Chromeno[4,3‐ b ]pyrrolidine derivatives are a class of compounds featuring a unique tricyclic fused scaffold and exhibiting significant biological activities. In recent years, remarkable progress has been made in developing efficient synthetic strategies for these complex structures. This review aims to systematically summarize various methods for synthesizing chromeno[4,3‐ b ]pyrrolidine derivatives. Based on the type of catalyst employed, we have summarized and categorized four main catalytic strategies: Brønsted base catalysis, N ‐heterocyclic carbene catalysis, phosphine catalysis, and metal catalysis. The cyclization strategies and their proposed reaction mechanisms are discussed in detail, and we believe this review will provide valuable inspiration for future innovative research in this field.
Authors
- Bingjie Li (ORCID: https://orcid.org/0000-0002-6540-5557)
- Yan Gao
- Er‐Qing Li (ORCID: https://orcid.org/0000-0003-1286-6832)
- Li Li
- Yue Wang (ORCID: https://orcid.org/0009-0006-7655-1468)
Institutions
- Shantou University (CN)
- Henan University of Technology (CN)
- Zhengzhou University (CN)
- Jiaozuo University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-05-09
- DOI
- https://doi.org/10.1002/ejoc.70535
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Henan Province