Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections
T-cell responses. Furthermore, the nanoplatform induced robust immune memory, characterized by expanded memory T-cell pools and elevated IgG levels, effectively preventing reinfection. Importantly, CS-BT@MZ@NEs showed no systemic toxicity. These findings highlight CS-BT@MZ@NEs as a novel therapeutic platform that integrates targeted delivery, Golgi pH modulation, and immune memory activation, offering a promising solution for IAIs treatment and advancing the field of nano-immunotherapy.
Authors
- Chun Zhou (ORCID: https://orcid.org/0000-0002-9257-468X)
- Shicheng Huo (ORCID: https://orcid.org/0000-0002-9047-8846)
- Zhuocheng Lyu (ORCID: https://orcid.org/0000-0003-1986-5605)
- Yaochao Zhao (ORCID: https://orcid.org/0000-0002-1448-5681)
- Yifei Liu (ORCID: https://orcid.org/0000-0002-4571-2226)
- Changgui Shi
- Naifeng Zhu
- Zhenjiang Xu
Institutions
- Second Military Medical University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/advs.75623
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China