Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square‐Wave Voltammetry and LC‐MS/MS Analysis

levels (p < 0.05) compared to WT DNA suggesting guanine content varied due to the genetic alterations, which was statistically more significant in leg muscle DNA. MS/MS validated and expanded on the SWV results. DNA base analysis showed increased oxidative damage alongside changes in undamaged base content in mdx mice. DNA from col5a1(+/-) leg muscles exhibited significant changes to undamaged base content, showcasing similar trends.

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Publication Details

Journal
ChemBioChem
Published
2026-05-10
DOI
https://doi.org/10.1002/cbic.70368
Primary Topic
Mitochondrial Function and Pathology
Type
article
Field-Weighted Citation Impact
0.00

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article

Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square‐Wave Voltammetry and LC‐MS/MS Analysis

Espen E. Spangenburg, Andrew T. Readyoff, Elizabeth R. LaFave, Saphal Bhandari et al.
ChemBioChem
Mitochondrial Function and Pathology
article

Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square‐Wave Voltammetry and LC‐MS/MS Analysis

Espen E. Spangenburg, Andrew T. Readyoff, Elizabeth R. LaFave, Saphal Bhandari, Grayson B. Sink, Emma L. Rayfield, Eli G. Hvastkovs
article en

Abstract

levels (p < 0.05) compared to WT DNA suggesting guanine content varied due to the genetic alterations, which was statistically more significant in leg muscle DNA. MS/MS validated and expanded on the SWV results. DNA base analysis showed increased oxidative damage alongside changes in undamaged base content in mdx mice. DNA from col5a1(+/-) leg muscles exhibited significant changes to undamaged base content, showcasing similar trends.

ChemBioChemVol. 27(9)
East Carolina University (US)
National Science Foundation, National Institutes of Health
Openalex Percentile: Top 8%
Mitochondrial Function and Pathology
DOISourceOpenAlex
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Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square‐Wave Voltammetry and LC‐MS/MS Analysis — Espen E. Spangenburg, Andrew T. Readyoff, et al. · ChemBioChem (2026) | TGRS Research Map | TGRS