Short-Term Visual and Optical Performance of the ZEISS CT LUCIA 621P Intraocular Lens Across Different Power Ranges

Purpose: To evaluate the short-term efficacy and optical performance of the ZEISS CT LUCIA 621P intraocular lens (IOL) in cataract patients using a diopter (D)-stratified approach. Patients and Methods: This retrospective study included 304 eyes of 216 patients who underwent phacoemulsification with CT LUCIA 621P implantation. Eyes were stratified into four groups by implanted IOL power: Group 1 (< 20.0 D, n=49), Group 2 (20.0– 21.5 D, n=137), Group 3 (22.0– 23.5 D, n=60), and Group 4 (≥ 24.0 D, n=58). Primary outcomes were monocular and binocular photopic/mesopic defocus curves and internal higher-order aberrations (HOAs) at 1 and 3 months because these directly evaluate the optical quality and depth of focus delivered by the non-constant aspheric ZEISS Optic design—the core innovative feature of the CT LUCIA 621P IOL—across the full spectrum of implanted powers. Secondary outcomes provide complementary clinical efficacy data; uncorrected and corrected distance visual acuity (UDVA/CDVA), uncorrected intermediate (UIVA) and near (UNVA), refractive predictability, and contrast sensitivity (CS). Analyses used generalized estimating equations (GEE) with an exchangeable correlation structure. Results: All groups achieved excellent refractive predictability with convergence of spherical equivalent (SE) toward emmetropia (p=0.398). Mean monocular UDVA at 3 months was comparable across groups (p=0.498). Monocular and binocular UIVA and UNVA were also comparable (all p> 0.23). Photopic and mesopic defocus curves showed similar depth of focus across groups (p> 0.05 at most levels). Postoperative spherical aberration (SA) and coma remained low with no significant inter-group differences after generalized GEE adjustment (p> 0.17). Photopic CS was comparable across IOL power groups at most spatial frequencies. Conclusion: The CT LUCIA 621P IOL demonstrated consistent refractive predictability, VA across distances, and optical quality across a wide range of implanted powers, supporting its reliable use in contemporary cataract surgery. Keywords: CT LUCIA 621P, non-constant aspheric IOL, ZEISS optic, diopter-stratified analysis, visual performance, optical quality, cataract surgery