Evaluating the Influence of Injury‐Induced Microstructural Variations on the Efficacy of a Diffusion <scp>MRI</scp> ‐Derived Axon Diameter Surrogate
PURPOSE: ) under pathologic conditions induced by a spinal cord injury model. METHODS: ) as well as longitudinal relaxometry based metrics and effective axon diameter from SEM were evaluated across regions of interest in slices 2-5 mm away from the injury epicenter. RESULTS: across slices. CONCLUSION: serves as a robust surrogate for axon diameter and provides complementary information to longitudinal relaxometry derived metrics.
Authors
- Hannah Alderson (ORCID: https://orcid.org/0009-0009-0408-4831)
- Mark D. Does (ORCID: https://orcid.org/0000-0003-2701-6208)
- Kevin D. Harkins (ORCID: https://orcid.org/0000-0003-3579-9273)
- Chaoqi Mu (ORCID: https://orcid.org/0000-0001-7082-9242)
- Li Min Chen
Institutions
- Vanderbilt University (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/mrm.70415
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health