Practical dose ranges supporting target vancomycin exposure with AUC‐guided dosing in overweight and obese patients: A multicentre retrospective study
AIM: Evidence supporting area under the concentration-time curve (AUC)-guided vancomycin dosing in overweight and obese patients remains limited. This multicentre retrospective study aimed to identify pragmatic loading dose (LD) and maintenance dose (MD) ranges associated with target AUC attainment in this population. METHODS: : 400-600 μg·h/mL). RESULTS: , respectively. CONCLUSION: , informing interim renal-stratified MD ranges until TDM results become available. Early TDM remains essential given significant inter-individual variability.
Authors
- Shun Tsujimura
- Yoshiaki Yokoyama
- Yuki Hanai (ORCID: https://orcid.org/0000-0002-4606-7150)
- Hideki Hashi (ORCID: https://orcid.org/0000-0002-8553-8592)
- Aiju Endo (ORCID: https://orcid.org/0000-0003-4534-8433)
- Kazumi Hanawa
- T Namiki (ORCID: https://orcid.org/0009-0000-4710-9693)
- Yuki Igarashi (ORCID: https://orcid.org/0009-0002-1936-910X)
- Daiki Asakawa
- Kaori Matsumoto
- Kazuaki Matsumoto
- Riku Maruyama
- Yuki Enoki
Institutions
- Toho University (JP)
- Chiba Institute of Science (JP)
- Keio University (JP)
- Kameda Medical Center (JP)
- Juntendo University Urayasu Hospital (JP)
- Yamanashi Prefectural Central Hospital (JP)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/bcp.70594
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00