From Structure to Function: COX‐Selective Anti‐Inflammatory Activity of Cu(II) and Zn(II) Hydrazone Complexes
value of 0.41 µM and a selectivity index of 307.32, indicating potential as a broad-spectrum anti-inflammatory agent. Molecular docking studies supported these results, revealing favorable binding energies and stable interactions of the metal complexes within COX active sites. Overall, these findings emphasize the role of metal coordination in enhancing enzyme binding and biological activity.
Authors
- Arun Kumar Singh (ORCID: https://orcid.org/0000-0002-2032-2694)
- R Vinodh Kumar
- Riya Kumari
- L. B. Prasad
- M.K. Bharty
- Ramesh Chandra
- Ram Nayan Gautam
- Diptee Mitra
Institutions
- University of Lucknow (IN)
- Maharaja Engineering College (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- ChemBioChem
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/cbic.70374
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00