Palatable‐Food–Driven Top‐Down Circuit Inhibits PVN <sup>CRF</sup> Activity to Mitigate Stress Via Peri‐PVN <sup>CRFR1</sup> Neurons
neurons is mediated indirectly via peri-PVN GABAergic inputs. These findings define a previously uncharacterized PFC→peri-PVN→PVN circuit through which hedonic experience modulates stress responses and reveal a neural substrate for behavioral resilience, providing a potential avenue for anxiety intervention.
Authors
- Tianjiao Deng
- Gaojie Shao
- Tianwen Huang (ORCID: https://orcid.org/0000-0001-5039-6259)
- Shirui Jun (ORCID: https://orcid.org/0000-0003-1594-7590)
- Jie Tu (ORCID: https://orcid.org/0000-0002-1432-5784)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Y W Sun (ORCID: https://orcid.org/0000-0002-4420-5708)
- Yuchuan Hong
- Fan Yang (ORCID: https://orcid.org/0000-0003-0563-3395)
- Qian Xiao
- Dan Liu
- Sheng Wang (ORCID: https://orcid.org/0000-0001-9579-4808)
- Jie Shao (ORCID: https://orcid.org/0000-0003-0904-7457)
Institutions
- Hebei Medical University (CN)
- Institute of Forensic Science (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1002/advs.75604
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Shenzhen Science and Technology Innovation Program