SINAT proteins modulate autophagic vesicle degradation by regulating V-ATPase subunit proteolysis in Arabidopsis
led to impaired starvation-induced autophagic vesicle degradation by disrupting V-ATPase activity mediated vacuolar acidification. Consistently, lysines K34 and K221 of VAB1 protein contributed to SINAT1-mediated ubiquitination, destabilization, and suppression of autophagy-associated nutrient starvation tolerance. Thus, our findings demonstrate that SINAT proteins are involved in autophagy regulation by modulating VAB1-mediated autophagic degradation in Arabidopsis.
Authors
- 薛澤杰
- Shunkang Zhou (ORCID: https://orcid.org/0000-0003-0764-9390)
- Qingqi Lin
- 茂信 林
- Dongwei Huang (ORCID: https://orcid.org/0000-0002-6715-1300)
- Ruohan Xie
- Sen Lu (ORCID: https://orcid.org/0000-0002-6565-7869)
- Shi Xiao
- Hua Qi (ORCID: https://orcid.org/0000-0002-7847-5079)
- Lijuan Xie
- Rongliang Qiu
- Yao Wang
Institutions
- South China Agricultural University (CN)
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-05-10
- DOI
- https://doi.org/10.1080/15548627.2026.2668859
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province