Mechanistic Insights into Flavonoids in Cosmetic Applications: Multifunctional Roles and Formulation Considerations

Nan Guo,1 Shiyu Zhong,2 Yuhan Wang3 1Rehabilitation Aesthetics, Medical College, Xi’an International University, Xi’an City, Shaanxi Province, People’s Republic of China; 2Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of China; 3Department of Beauty Art Care, Graduate School, Dongguk University, Seoul, South KoreaCorrespondence: Shiyu Zhong, Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 of Xiwu Road, Xincheng District, Xi’an City, Shaanxi Province, Email [email protected]: Flavonoids are plant secondary metabolites commonly found in fruits and seeds, contributing to color, aroma, and taste. They play key roles in growth regulation, pollinator attraction, and stress defense. Structurally characterized by their polyphenolic nature, flavonoids contribute to skin health through multiple mechanisms. These compounds contribute to skin health through well-characterized mechanisms, including inhibition of tyrosinase, scavenging of reactive oxygen species, and modulation of inflammatory signaling pathways such as NF-κB. As a result, flavonoids have demonstrated efficacy in skin whitening, antioxidant defense, anti-inflammatory action, and antimicrobial protection. They also promote skin hydration and elasticity by enhancing epidermal barrier function and stimulating the synthesis of collagen and hyaluronic acid. The multifunctional nature of flavonoids positions them as promising natural alternatives to synthetic cosmetic ingredients, particularly in formulations targeting acne, sensitivity, aging, and pigmentation. Although their cosmetic potential is well supported, challenges such as formulation stability, delivery efficiency, and variation in cutaneous absorption continue to limit their widespread application. This review highlights the diverse applications of flavonoids in cosmetics, underscoring their potential to address key skin concerns while advancing natural product innovation.Keywords: flavone, function, cosmetic, skin